AV-105 是一种 Florbetapir (18F)-放射性标记的 slyrylpyridine 磺酸酯前体。AV-105 可以合成 18F-放射性标记的化合物，可用于大脑神经退行性疾病的正电子发射断层扫描 (PET) 成像。
货号:ajcx29138
CAS:1205550-99-7
分子式:C32H40N2O8S
分子量：612.73
溶解度:DMSO: 62.5 mg/mL (102.00 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AV-105 is a Florbetapir (18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize 18F-radiolabeled compounds, which are used for positron emission tomography (PET) imaging of neurodegenerative diseases of the brain[1].

The AV-105 synthesis method utilizes a primary tosylate instead of a primary mesylate as an active leaving group. Use of the tosylate precursor for radiofluorination is beneficial, at least for the reason that the tosylate generated during the radiofluorination reaction is readily removed by chromatographic means from the 18F-radiolabeled imaging product[1].

[1]. Tyler Benedum, et al. Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof. WO2010078370A1.