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Lys-(Des-Arg9,Leu8)-Bradykinin(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lys-(Des-Arg9,Leu8)-Bradykinin(trifluoroacetate salt)图片
规格:98%
分子量:998.2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
A bradykinin B1 receptor antagonist
货号:ajcx26748
CAS:N/A
分子式:C47H75N13O11 • XCF3COOH
分子量:998.2
溶解度:DMF: 1 mg/ml,DMSO: 3 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Lys-(Des-Arg9, Leu8)-Bradykinin is a bradykinin B1receptor antagonist (Ki= 0.43 nM for the rabbit aorta receptor).1It is selective for the bradykinin B1over the B2receptor (Ki= >10 µM for the rabbit ileum receptor).2Lys-(Des-Arg9, Leu8)-Bradykinin inhibits contractions induced by the bradykinin B1receptor agonist Des-Arg9-bradykinin in isolated rabbit aortic rings (pA2= 8.54).3Intraperitoneal administration of Lys-(Des-Arg9, Leu8)-bradykinin (5 mg/kg per day for three days) reduces increases in paw edema in a rat model of arthritis induced by peptidoglycan-polysaccharide (PGPS).4

1.MacNeil, T., Bierilo, K.K., Menke, J.G., et al.Cloning and pharmacological characterization of a rabbit bradykinin B1 receptorBiochim. Biophys. Acta1264(2)223-228(1995) 2.Meini, S., Cucchi, P., Catalani, C., et al.Radioligand binding characterization of the bradykinin B2 receptor in the rabbit and pig ileal smooth muscleEur. J. Pharmacol.635(1-3)34-39(2010) 3.Drapeau, G., Audet, R., Levesque, L., et al.Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kininsJ. Pharmacol. Exp. Ther.266(1)192-199(1993) 4.Blais, C., Jr., Couture, R., Drapeau, G., et al.Involvement of endogenous kinins in the pathogenesis of peptidoglycan-induced arthritis in the Lewis ratArthritis Rheum.40(7)1327-1333(1997)