A peptide opioid receptor agonist
货号:ajcx26734
CAS:N/A
分子式:C27H36N6O6S • XCF3COOH
分子量：572.7
溶解度:DMF: 2 mg/ml,DMSO: 10 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 2 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Met-Enkephalinamide is a peptide opioid receptor agonist and derivative of Met-enkephalin .^1,2It binds to opioid receptors in rat cerebellum homogenates (IC₅₀= 0.2 µM) and reduces the twitch height in electrically stimulated isolated guinea pig ileum and isolated mouse vas deferens. Met-Enkephalinamide (300 µg/animal) induces analgesia in the hot plate and tail-flick tests in rats, effects that can be reversed by administration of the opioid receptor antagonist naloxone.³

1.Change, J.-K., and Fong, B.T.W.Opiate receptor affinities and behavioral effects of enkephalin: Structure-activity relationship of ten synthetic peptide analoguesLife Sci.18(12)1473-1481(1976) 2.Quinn, M.J., Laska, F.J., and Fennessy, M.R.Structure-activity relationships of met5- and leu5-enkephalin analoguesClin. Exp. Pharmacol. Physiol.6535-540(1979) 3.Yaksh, T.L., Huang, S.P., and Rudy, T.A.The direct and specific opiate-like effect of Met5-enkephalin and analogues on the spinal cordNeuroscience2(4)593-596(1977)