An antiviral nucleoside analog
货号:ajcx26660
CAS:84472-85-5
分子式:C9H11N5O4
分子量：253.2
溶解度:DMF: 2 mg/ml,DMSO: 2 mg/ml,Ethanol: insol,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

3’-Azido-2’,3’-dideoxyuridine (AZddU) is an antiviral nucleoside analog.¹It is phosphorylated by thymidine kinase.²AZddU inhibits cytopathogenicity induced by HIV or Moloney sarcoma virus (MSV) in MT-4 cells (EC₅₀s = 0.36 and 15 µM, respectively).¹

1.Balzarini, J., Baba, M., Pauwels, R., et al.Anti-retrovirus activity of 3’-fluoro- and 3’-azido-substituted pyrimidine 2’,3’-dideoxynucleoside analoguesBiochem. Pharmacol.37(14)2847-2856(1988) 2.Eriksson, B.F., Chu, C.K., and Schinazi, R.F.Phosphorylation of 3’-azido-2’,3’-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5’-triphosphateAntimicrob. Agents Chemother.33(10)1729-1734(1989)