An internal standard for the quantification of isoproterenol
货号:ajcx25646
CAS:2517584-04-0
分子式:C11H10D7NO3·HCl
分子量：254.8
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Isoproterenol-d₇is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β₁- and β₂-adrenergic receptors (β₁- and β₂-ARs; K_is = 224 and 458 nM, respectively).¹It is selective for β₁- and β₂-ARs over β₃-ARs (K_i= 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC₅₀= 45.6 nM).²In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectomized rats.³It reduces blood pressure and increases heart rate in renal hypertensive rabbits.⁴Isoproterenol inhibits histamine-induced bronchospasms in anesthetized dogs.⁵Formulations containing isoproterenol have been used in the treatment of bradydysrhythmias and to improve breathing during anesthesia.

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