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Ipidacrine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ipidacrine图片
规格:98%
分子量:188.3
包装与价格:
包装价格(元)
500mg电议
1g电议
5g电议

产品介绍
2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-amine 是一种药物活性化合物,是一种促智剂,可作为胆碱酯酶抑制剂,用于治疗阿尔茨海默病 [1 ]。
货号:ajcx25560
CAS:62732-44-9
分子式:C12H16N2
分子量:188.3
溶解度:DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ipidacrine is an inhibitor of acetylcholinesterase (AChE; IC50= 270 nM).1It induces long-term potentiation (LTP) in rat hippocampal slices, an effect that can be blocked by the muscarinic antagonists atropine or pirenzepine , when used at a concentration of 10 µM.2Ipidacrine (0.03-1 mg/kg) prevents memory deficits induced by the anticholinergic agent scopolamine in the passive avoidance test in rats.2


1.Ogura, H., Kosasa, T., Kuriya, Y., et al.Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitroMethods Find. Exp. Clin. Pharmacol.22(8)609-613(2000) 2.Yoshida, S., and Suzuki, N.Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in ratsEur. J. Pharmacol.250(1)117-124(1993)