An active metabolite of carbamazepine
货号:ajcx25200
CAS:36507-30-9
分子式:C15H12N2O2
分子量：252.3
溶解度:DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.^1,2It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells expressing CYP3A4 or CYP2C8, respectively.¹Carbamazepine 10,11-epoxide has anticonvulsant activity against maximal electroshock-induced seizures in mice.²It has been found in wastewater effluent.³

1.Kerr, B.M., Thummel, K.E., Wurden, C.J., et al.Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formationBiochem. Pharmacol.47(11)1969-1979(1994) 2.Bourgeois, B.F., and Wad, N.Individual and combined antiepileptic and neurotoxic activity of carbamazepine and carbamazepine-10,11-epoxide in miceJ. Pharmacol. Exp. Ther.231(2)411-415(1984) 3.Miao, X.-S., Yang, J.-J., and Metcalfe, C.D.Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plantEnviron. Sci. Technol.39(19)7469-7475(2005)