您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Azelastine-13C-d3(hydrochloride)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Azelastine-13C-d3(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azelastine-13C-d3(hydrochloride)图片
规格:98%
分子量:422.4
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of azelastine
货号:ajcx25092
CAS:N/A
分子式:C21[13C]H21ClD3N3O·HCl
分子量:422.4
溶解度:DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Azelastine-13C-d3is intended for use as an internal standard for the quantification of azelastine by GC- or LC-MS. Azelastine is a histamine H1receptor antagonist (Ki= 1.26 nM in bovine cerebral cortex membranes).1It is selective for histamine H1over histamine H3receptors (Ki= 158.49 nM), as well as α1A- and α1B-adrenergic receptors (Ki= 50.12 nM for both). Azelastine (0.14 µg/animal) reduces nose rubbing, sneezing, and nasal mucosa expression of IL-4 in a dust mite-induced mouse model of allergic rhinitis.2It also reduces infection by a lentivirus pseudotyped with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein, also known as the surface glycoprotein, in HEK293 cells expressing angiotensin-converting enzyme 2 (ACE2) when used at a concentration of 7 µg/ml.3Formulations containing azelastine have been used in the treatment of seasonal allergic rhinitis and vasomotor rhinitis.


1.Procopiou, P.A., Browning, C., Buckley, J.M., et al.The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitisJ. Med. Chem.54(7)2183-2195(2011) 2.Sun, S., Dean, R., Jia, Q., et al.Discovery of XEN445: A potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in miceBioorg. Med. Chem.21(24)7724-7734(2013) 3.Reznikov, L.R., Norris, M.H., Vashisht, R., et al.Identification of antiviral antihistamines for COVID-19 repurposingBiochem. Biophys. Res. Commun.538173-179(2021)