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CAY17c
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAY17c图片
规格:98%
分子量:470.6
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An inhibitor of BRD4 and class I and class IIb HDACs
货号:ajcx25038
CAS:2414373-11-6
分子式:C24H30N4O4S
分子量:470.6
溶解度:DMF: slightly soluble,DMSO: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 µM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 µM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 µM for HDAC6 and HDAC10, respectively).1It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 µM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 µM for all). CAY17c inhibits the proliferation of HCT116, SW620, and DLD-1 colorectal cancer cells (IC50s = 0.45, 1.78, and 2.11 µM, respectively), as well as induces apoptosis and autophagy in HCT116 cells. It reduces tumor growth in an HCT116 mouse xenograft model when administered at doses of 15 and 30 mg/kg.


1.Pan, Z., Li, X., Wang, Y., et al.Discovery of thieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as bromodomain-containing protein 4/histone deacetylase dual inhibitors induce autophagic cell death in colorectal carcinoma cellsJ. Med. Chem.63(7)3678-3700(2020)