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Phenytoin-d10
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phenytoin-d10图片
规格:98%
分子量:262.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An internal standard for the quantification of phenytoin
货号:ajcx24732
CAS:65854-97-9
分子式:C15H2D10N2O2
分子量:262.3
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Phenytoin-d10is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin . Phenytoin is formed from fosphenytoin by tissue phosphatases.1It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner.2Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal slices (EC50s = 42.8 and 33.5 µM, respectively).3It protects against seizures induced by maximal electroshock (MES) in mice (ED50= 10 mg/kg).4Formulations containing phenytoin have been used in the treatment of tonic-clonic seizures and status epilepticus.


1.Boucher, B.A.Fosphenytoin: A novel phenytoin prodrugPharmacotherapy16(5)777-791(1996) 2.Yaari, Y., Selzer, M.E., and Pincus, J.H.Phenytoin: Mechanisms of its anticonvulsant actionAnn. Neurol.20(2)171-184(1986) 3.Calabresi, P., Centonze, D., Marfia, G.A., et al.An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neuronsBr. J. Pharmacol.126(3)689-696(1999) 4.Brouillette, W.J., Jestkov, V.P., Akhtar, M.S., et al.Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channelJ. Med. Chem.37(20)3289-3293(1994)