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Gliclazide-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gliclazide-d4图片
规格:98%
分子量:327.4
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of gliclazide
货号:ajcx24544
CAS:1185039-30-8
分子式:C15H17D4N3O3S
分子量:327.4
溶解度:DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Gliclazide-d4is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels (IC50= 184 nM for murine β-cells).1,2It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATPchannels (IC50s = 19.5 and 37.9 μM, respectively).1Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin resistance induced by hydrogen peroxide.3Gliclazide (5 and 10 μg/ml) reduces LDL oxidation by human aortic smooth muscle cells (HASMCs), decreasing TBARS content and 8-isoprostane levels.4It also decreases oxidized LDL-induced HASMC proliferation and monocyte adhesion when used at concentrations ranging from 1 to 10 μg/ml. Gliclazide (5 mg/kg) reduces serum glucose levels and increases glucose uptake by isolated rat hindquarters in a model of diabetes induced by streptozotocin .5


1.Lawrence, C.L., Proks, P., Rodrigo, G.C., et al.Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cellsDiabetologia44(8)1019-1025(2001) 2.Proks, P., Reimann, F., Green, N., et al.Sulfonylurea stimulation of insulin secretionDiabetes51(3)S368-S376(2002) 3.Shimoyama, T., Yamaguchi, S., Takahashi, K., et al.Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocationMetabolism55(6)722-730(2006) 4.Mamputu, J.C., and Renier, G.Gliclazide decreases vascular smooth muscle cell dysfuntion induced by cell-meditated oxidized low-density lipoproteinMetabolism50(6)688-695(2001) 5.Pulido, N., Suarez, A., Casanova, B., et al.Gliclazide treatment of streptozotocin diabetic rats restores GLUT4 protein content and basal glucose uptake in skeletal muscleMetabolism46(12 Suppl 1)10-13(1997)