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Naftopidil-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Naftopidil-d5图片
规格:98%
分子量:397.5
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
C24H23D5N2O3
货号:ajcx24312
CAS:N/A
分子式:C24H23D5N2O3
分子量:397.5
溶解度:Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Naftopidil-d5is intended for use as an internal standard for the quantification of naftopidil by GC- or LC-MS. Naftopidil is an antagonist of α1-adrenergic receptors (α1-ARs; Kis = 3.7, 20, and 1.2 nM for α1A-, α1B-, and α1D-ARs, respectively).1It is selective for α1-ARs over α2-ARs (Ki= 1,793 nM).2Naftopidil inhibits norepinephrine-induced contractions in various blood vessels isolated from dog, rabbit, guinea pig, or rat with pA2values ranging from 6.73 to 8.15.2It reduces prostatic pressure and mean blood pressure in anesthetized dogs when administered at doses of 100 or 1,000 µg/kg.3Naftopidil also inhibits the growth of androgen-sensitive LNCaP cells and androgen-insensitive PC3 cancer cells with IC50values of 22.2 and 33.2 µM, respectively.4Formulations containing naftopidil have been used in the treatment of benign prostatic hyperplasia.


1.Masumori, N.Naftopidil for the treatment of urinary symptoms in patients with benign prostatic hyperplasiaTher. Clin. Risk Manag.7227-238(2011) 2.Muramatsu, I., Yamanaka, K., and Kigoshi, S.Pharmacological profile of the novel α-adrenoceptor antagonist KT-611 (naftopidil)Jpn. J. Pharmacol.55(3)391-398(1991) 3.Takei, R.-i., Ikegaki, I., Shibata, K., et al.Naftopidil, a novel α1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human α1-adrenoceptorsJpn. J. Pharmacol.79(4)447-454(1999) 4.Kanda, H., Ishii, K., Ogura, Y., et al.Naftopidil, a selective α-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrestInt. J. Cancer122(2)444-451(2008)