An active metabolite of ibrutinib
货号:ajcx24152
CAS:1654820-87-7
分子式:C25H26N6O4
分子量:474.5
溶解度:Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:
现货Background:
PCI 45227 is an active metabolite of the Bruton's tyrosine kinase inhibitor ibrutinib .1PCI 45227 is formed from ibrutinib by the cytochrome P450 (CYP) isoform CYP3A.
1.Veeraraghavan, S., Viswanadha, S., Thappali, S., et al.Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: Application to a pharmacokinetic studyJ. Pharm. Biomed. Anal.107151-158(2015)