规格: | 98% |
分子量: | 478.6 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Background:
Diflucortolone 21-valerate is a glucocorticoid.1It has anti-inflammatory effects in a rat model of croton oil-induced ear edema when applied topically (ED50= 9.7 µg/ml).2Diflucortolone 21-valerate (0.1%) also induces skin inflammation and thins the epidermis in hairless dogs following chronic topical administration and increases allergic- and non-allergic-mediated skin inflammation in mouse models of atopic dermatitis when applied topically prior to and following sensitization.3,1Formulations containing diflucortolone 21-valerate have been used in the treatment of inflammatory or allergic skin conditions.
1.Igawa, K., Katayama, I., Minatohara, K., et al.Topical glucocorticoid augments both allergic and non-allergic cutaneous reactions in mice when applied at the afferent stage of contact sensitivityAllergol. Int.46(1)33-41(1997) 2.Yamada, K., Hattori, S., Hakoda, T., et al.A fundamental study on a bioassay for the antiphlogistic effect of topically applied antiinflammatory agentsNihon Yakurigaku Zasshi75(8)789-798(1979) 3.Kimura, T., and Doi, K.Dorsal skin reactions of hairless dogs to topical treatment with corticosteroidsToxicol. Pathol.27(5)528-535(1999)