包装: | 1mg |
规格: | 98% |
市场价: | 3985元 |
分子量: | 507.6 |
Background:
Quetiapine-d8is intended for use as an internal standard for the quantification of quetiapine by GC- or LC-MS. Quetiapine is an atypical, second generation antipsychotic compound.1,2,3It has effects at multiple receptors, antagonizing dopamine D1, D2, and D3receptors (Kis = 994, 379, and 340 nM, respectively), serotonin 5-HT1A, 5-HT2A, and 5-HT7receptors (Kis = 394, 118, and 307 nM, respectively), and α1A, α1B, and α2Cadrenergic receptors (Kis = 22, 15, and 29 nM, respectively).4,5Quetiapine also potently antagonizes the histamine H1receptor (Ki= 11 nM).5
1.Seeman, P.Atypical antipsychotics: Mechanism of actionCan. J. Psychiatry47(1)27-38(2002) 2.Rummel-Kluge, C., Komossa, K., Schwarz, S., et al.Second-generation antipsychotic drugs and extrapyramidal side effects: A systematic review and meta-analysis of head-to-head comparisonsSchizophr. Bull.38(1)167-177(2012) 3.Cerejeira, J., and Mukaetova-Ladinska, E.B.A clinical update on delirium: From early recognition to effective managementNurs. Res. Pract.875196(2011) 4.Richelson, E., and Souder, T.Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compoundsLife Sci.68(1)29-39(2000) 5.Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugsNeuropsychopharmacology28(3)519-526(2003)