| 规格: | 98% |
| 分子量: | 533 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
Background:
Barnidipine-d5 (hydrochloride) is intended for use as an internal standard for the quantification of barnidipine by GC- or LC-MS. Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery.1It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day.2Formulations containing barnidipine have been used in the treatment of hypertension.
1.Nakayama, K., Kashiwabara, T., Yamada, S., et al.Assessment in pig coronary artery of long-lasting and potent calcium antagonistic actions of the novel dihydropyridine derivative mepirodipine hydrochlorideArzneimittelforschung39(1)50-55(1989) 2.Kawashima, K., Toda, H., Oohata, H., et al.Antihypertensive and diuretic effects of YM-09730-5, a new calcium antagonist, in stroke-prone spontaneously hypertensive ratsGen. Pharmacol.22(2)263-266(1991)
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