An internal standard for the quantification of chlorhexidine
货号:ajcx24000
CAS:2012598-75-1
分子式:C22H22Cl2D8N10•2HCl
分子量：586.4
溶解度:DMSO: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Chlorhexidine-d₈is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is abis(biguanide) antimicrobial disinfectant and antiseptic agent.¹It inhibits growth of clinical methicillin-resistantS. aureus(MRSA) isolates (MIC₉₀= 4 μg/ml).²It is also active against canine isolates of MRSA, methicillin-susceptibleS. aureus(MSSA), methicillin-resistantS. pseudintermedius(MRSP), and methicillin-susceptibleS. pseudintermedius(MSSP; MIC₉₀s = 4, 2, 2, and 1 mg/L, respectively).³Chlorhexidine inhibits growth ofE. faeciumstrains (MICs = 1.2-19.6 μg/ml) andC. albicans(MIC = 5.15 μg/ml).^4,5It generates cations that bind to and destabilize the bacterial cell wall to induce death.⁶Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 when used at concentrations of 0.0001 and 0.002%, respectively, in a gelatin degradation assay.⁷Formulations containing chlorhexidine have been used in antiseptic wound dressings, mouthwash, and toothpaste.

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