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Cefotiam(hydrochloride hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cefotiam(hydrochloride hydrate)图片
规格:98%
分子量:598.5
包装与价格:
包装价格(元)
500mg电议
1g电议
5g电议

产品介绍
C18H23N9O4S3•2HCl [XH2O]
货号:ajcx23992
CAS:N/A
分子式:C18H23N9O4S3•2HCl [XH2O]
分子量:598.5
溶解度:DMF: 5 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Cefotiam is a broad-spectrum cephalosporin antibiotic.1It inhibits the growth of the Gram-positive bacteriumS. aureus(MIC50= 0.26 µg/ml) and the Gram-negative bacteriaP. aeruginosa,E. coli, andH. influenzae(MIC50s = 1, 0.06, and 0.01 µg/ml, respectively). Cefotiam increases survival in mouse models of infection with the 853E and 630E strains ofS. aureus(ED50s = 3.5 and 8.3 mg/kg, respectively) and various strains ofE. coli(ED50s = 0.5-25 mg/kg).2Formulations containing cefotiam have previously been used in the treatment of bacterial infections.


1.Limbert, M., Klesel, N., Seeger, K., et al.Cefodizime, an aminothiazolylcephalosporin. I. In vitro activityJ. Antibiot. (Tokyo)37(8)892-900(1984) 2.Acred, P., Ryan, D.M., Sowa, M.A., et al.The in-vivo antibacterial activity of ceftazidime (Gr 20263)--a comparison with other new β-lactam antibiotics and gentamicinJ. Antimicrob. Chemother.8 Suppl. B247-255(1981)