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Trifluoperazine-d3(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trifluoperazine-d3(hydrochloride)图片
包装:1mg
规格:98%
市场价:2529元
分子量:483.4

产品介绍
An internal standard for the quantification of trifluoperazine
货号:ajcx23660
CAS:1432064-02-2
分子式:C21H21D3F3N3S.2HCl
分子量:483.4
溶解度:DMSO: slightly soluble,Methanol: slightly soluble,Water: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Trifluoperazine-d3is intended for use as an internal standard for the quantification of trifluoperazine by GC- or LC-MS. Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents.1It antagonizes adrenergic receptors, with selectivity for α1over the α2subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively). TFP binds with much higher affinity to the dopamine D2-like receptor (Kd= 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2Areceptors (Kds = 44 and 135 nM, respectively).2Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).3,4TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.4


1.Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugsNeuropsychopharmacology28(3)519-526(2003) 2.Seeman, P., Corbett, R., and Van Tol, H.H.Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptorsNeuropsychopharmacology16(2)93-110(1997) 3.Zimmer, M., and Hofmann, F.Calmodulin antagonists inhibit activity of myosin light-chain kinase independent of calmodulinEur. J. Biochem.142(2)393-397(1984) 4.Qin, J., Zima, A.V., Porta, M., et al.Trifluoperazine: A ryanodine receptor agonistPflugers Arch.458(4)643-651(2009)