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Tebufenozide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tebufenozide图片
规格:98%
分子量:352.5
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
Tebufenozide 是一种用于防治害虫的非甾体蜕皮激素激动剂。
货号:ajcx23568
CAS:112410-23-8
分子式:C22H28N2O2
分子量:352.5
溶解度:Chloroform: Slightly Soluble,Methanol: Slightly Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Tebufenozide is an insecticide that acts as a non-steroidal agonist of the insect ecdysone receptor (EcR; IC50= 0.85 nM in a cell-free preparation ofC. suppressalisintegument).1It induces a premature molt and is lethal toS. liturathird instar larva (LD50= 0.33 µM per larva).1,2It also inhibits p-glycoprotein activity in LLC-PK1 porcine kidney epithelial cells transfected with humanMDR1, the gene for p-glycoprotein (IC50= 21.5 µM).3Tebufenozide has low toxicity in mammals, birds, and most aquatic species, but it dose-dependently decreases colony formation and induces apoptosis and cell cycle arrest in HeLa cells when used at concentrations ranging from 50 to 200 µg/ml.4,5


1.Minakuchi, C., Nakagawa, Y., Kamimura, M., et al.Binding affinity of nonsteroidal ecdysone agonists against the ecdysone receptor complex determines the strength of their molting hormonal activityEur. J. Biochem.270(20)4095-4104(2003) 2.Yokoi, T., Minami, S., Nakagawa, Y., et al.Structure-activity relationship of imidazothiadiazole analogs for the binding to the ecdysone receptor of insect cellsPestic. Biochem. Physiol.12040-50(2015) 3.Miyata, K.-i., Nakagawa, Y., Kimura, Y., et al.Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transportBioorg. Med. Chem.24(14)3184-3191(2016) 4.Xu, W., Wang, B., Yang, M., et al.Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cellsEnviron. Toxicol. Pharmacol.4989-96(2017) 5.Abass, K.M.An investigation into the formation of tebufenozide's toxic aromatic amine metabolites in human in vitro hepatic microsomesPestic. Biochem. Physiol.13373-78(2016)