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SR 142948(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SR 142948(hydrochloride)图片
规格:98%
分子量:758.8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx23516
CAS:N/A
分子式:C39H51N5O6.2HCl
分子量:758.8
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 0.1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

SR 142948 is an orally bioavailable non-peptide antagonist of neurotensin receptors (NTS; IC50s = 1.19, 0.32, and 3.96 nM for human recombinant NTS receptors expressed in CHO cells, HT-29 cells, and adult rat brain membranes, respectively).1It inhibits inositol phosphate formation in HT-29 cells (IC50= 3.9 nM) and intracellular calcium accumulation in CHO cells expressing human NTS receptors. SR 142948 (1 mg/kg, i.v.) inhibits the firing rate of rat ventral pallidum neurons with a longer duration of action than the NTS receptor antagonist SR 48692 .2It also inhibits neurotensin-induced behavioral responses, including inhibition of neurotensin-induced turning behavior in mice when administered at doses ranging from 40 to 640 mg/kg and hypothermia and analgesia in rats and mice.1


1.Gully, D., Labeeuw, B., Boigegrain, R., et al.Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonistJ. Pharmacol. Exp. Ther.280(2)802-812(1997) 2.Michaud, J.-C., Gueudet, C., and SoubriÉ, P.Effects of neurotensin receptor antagonists on the firing rate of rat ventral pallidum neuronsNeuroreport11(7)1437-1441(2000)