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Silodosin-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Silodosin-d4图片
包装:1mg
规格:98%
市场价:8875元
分子量:499.6

产品介绍
An internal standard for the quantification of silodosin
货号:ajcx23474
CAS:1426173-86-5
分子式:C25H28D4F3N3O4
分子量:499.6
溶解度:Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Silodosin-d4is intended for use as an internal standard for the quantification of silodosin by GC- or LC-MS. Silodosin is an α1A-adrenergic receptor (α1A-AR) antagonist (Ki= 0.036 nM).1It is 583- and 56-fold selective for α1A- over α1B- and α1D-ARs, respectively. Silodosin inhibits phenylephrine-induced contraction of isolated rabbit prostate (pA2= 10.05) more potently than rabbit or rat aorta (pA2s = 9.36 and 8.13, respectively).2It inhibits norepinephrine-induced contraction of isolated human prostate tissue when used at concentrations ranging from 0.3 to 10 nM.1Silodosin (0.01-1,000 µg/kg) inhibits phenylephrine-induced increases in intraurethral pressure in rats.3Formulations containing silodosin have been used in the treatment of benign prostatic hyperplasia.


1.Moriyama, N., Akiyama, K., Murata, S., et al.KMD-3213, a novel α1A-adrenoceptor antagonist, potently inhibits the functional α1-adrenoceptor in human prostateEur. J. Pharmacol.331(1)39-42(1997) 2.Yamagishi, R., Akiyama, K., Nakamura, S., et al.Effect of JMD-3213, an α1a-adrenoceptor-selective antagonist, on the contractions of rabbit prostate and rabbit and rat aortaEur. J. Pharm.315(1)73-79(1996) 3.Akiyama, K., Hora, M., Tatemichi, S., et al.KMD-3213, a uroselective and long-acting α1a-adrenoceptor antagonist, tested in a novel rat modelJ. Pharmacol. Exp. Ther.291(1)81-91(1999)