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Rifampicin-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rifampicin-d3图片
包装:500ug
规格:98%
市场价:3689元
分子量:826

产品介绍
An internal standard for the quantification of rifampicin
货号:ajcx23422
CAS:1262052-36-7
分子式:C43H55D3N4O12
分子量:826
溶解度:Chloroform: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Rifampicin-d3is intended for use as an internal standard for the quantification of rifampicin by GC- or LC-MS. Rifampicin is a rifamycin antibiotic and inhibitor of bacterial RNA polymerase (IC50= 0.01 μg/ml for theE. colienzyme).1It inhibits the growth ofM. tuberculosisH37Rv in mouse peritoneal macrophages (MIC = 0.8 μg/ml) as well as clinical isolates of various species ofStaphylococcus,Streptococcus,Haemophilus, andNeisseria(MICs = 0.009-1.4 μg/ml).2,3Rifampicin increases survival in a mouse model of tuberculosis infection.3It is also an agonist of the human pregnane X receptor (PXR; EC50= ~2 μM).4Formulations containing rifampicin have been used in the treatment of tuberculosis and meningococcal carriers.


1.Wehrli, W.Rifampin: Mechanisms of action and resistanceRev.Infect.Dis.5(3)S407-S411(1983) 2.Jhamb, S.S., Goyal, A., and Singh, P.P.Determination of the activity of standard anti-tuberculosis drugs against intramacrophage Mycobacterium tuberculosis, in vitro: MGIT 960 as a viable alternative for BACTEC 460Braz. J. Infect. Dis.18(3)336-340(2014) 3.Arioli, V., Berti, M., Carniti, G., et al.Antibacterial activity of DL 473, a new semisynthetic rifamycin derivativeJ. Antibiot. (Tokyo)34(8)1026-1032(1981) 4.Gill, S.K., Xu, H., Kirchhoff, P.D., et al.Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerasesJournal of Medicinal Chemistry55(8)3814-3826(2012)