规格: | 98% |
分子量: | 743.4 |
包装 | 价格(元) |
50mg | 电议 |
100mg | 电议 |
500mg | 电议 |
1g | 电议 |
Background:
NADP+is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate . It serves as a cofactor in various biological reactions.1,2In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling.2,3For example, binding of NADP+to β-subunits of Kvchannels activates ion transport, whereas NADPH stabilizes channel inactivation.4NADP+is biosynthesized from NAD+by NAD kinase, with ATP as the phosphoryl donor.5
1.Jackson, J.B.A review of the binding-change mechanism for proton-translocating transhydrogenaseBiochimica et Biophysica Acta1817(10)1839-1846(2012) 2.Nakamura, M., Bhatnagar, A., and Sadoshima, J.Overview of pyridine nucleotides review seriesCirc. Res.111(5)604-610(2012) 3.Ziegler, M.A vital link between energy and signal transduction: Regulatory functions of NAD(P)FEBS Journal272(18)4561-4564(2014) 4.Kilfoil, P.J., Tipparaju, S.M., Barski, O.A., et al.Regulation of ion channels by pyridine nucleotidesCirc. Res.112(4)721-741(2013) 5.Shi, F., Li, Y., Li, Y., et al.Molecular properties, functions, and potential applications of NAD kinasesActa Biochim. Biophys. Sin. (Shanghai)41(5)352-361(2009)