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Estetrol(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Estetrol(hydrate)图片
规格:98%
分子量:304.4
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
A naturally occurring estrogen
货号:ajcx22444
CAS:N/A
分子式:C18H24O4.XH2O
分子量:304.4
溶解度:DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium).1,2In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.1,2


1.Coelingh Bennink, H.J.T., Holinka, C.F., and Diczfalusy, E.Estetrol review: Profile and potential clinical applicationsClimacteric.11(Suppl 1)47-58(2008) 2.Giretti, M.S., Guevara, M.M.M., Cecchi, E., et al.Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin CytoskeletonFront.Endocrinol.(Lausanne)5(80)1-8(2014)