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Eliglustat-d15(tartrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Eliglustat-d15(tartrate)图片
规格:98%
分子量:569.7
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of eliglustat
货号:ajcx22404
CAS:1884556-84-6
分子式:C23H21D15N2O4.C4H6O6
分子量:569.7
溶解度:DMSO: soluble,Methanol: soluble,Water: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Eliglustat-d15is intended for use as an internal standard for the quantification of eliglustat by GC- or LC-MS. Eliglustat is an inhibitor of glucosylceramide synthase (IC50= 40 nM for inhibition of glucosylceramide production in K562 cells).1It is selective for glucosylceramide synthase over α-glucosidase I and II, α-1,6-glucosidase, lysosomal glucocerebrosidase, non-lysosomal glucosylceramidase, sucrase, and maltase (IC50s = >10 µM for all). It decreases cell surface levels of the gangliosides GM1and GM3in K562 and B16/F10 cells with IC50values of 24 and 29 nM, respectively. Eliglustat (150 mg/kg per day) decreases glucosylceramide levels in the liver and lungs of D409V/null mice, a model of Gaucher disease. Formulations containing eliglustat have been used in the treatment of type 1 Gaucher disease.


1.McEachern, K.A., Fung, J., Komarnitsky, S., et al.A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher diseaseMol. Genet. Metab.91(3)259-267(2007)