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Dronedarone-d6(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dronedarone-d6(hydrochloride)图片
包装:1mg
规格:98%
市场价:5111元
分子量:599.3

产品介绍
An internal standard for the quantification of dronedarone
货号:ajcx22378
CAS:1329809-23-5
分子式:C31H38D6N2O5S.HCl
分子量:599.3
溶解度:Chloroform: Slightly soluble,Methanol: Slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Dronedarone-d6is intended for use as an internal standard for the quantification of dronedarone by GC- or LC-MS. Dronedarone is an antiarrhythmic agent and a derivative of amiodarone .1,2It inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively).2Dronedarone (50 and 100 mg/kg) reduces sinus frequency and prolongs action potential duration (APD) in isolated rabbit ventricular myocardium. It increases atrial APD and the atrial effective refractory period (AERP) in a dog model of atrial fibrillation induced by rapid right atrial pacing.3Formulations containing dronedarone have been used in the treatment of atrial fibrillation.


1.Sun, W., Sarma, J.S., and Singh, B.N.Electrophysiological effects of dronedarone (SR33589), a noniodinated benzofuran derivative, in the rabbit heart: Comparison with amiodaroneCirculation100(22)2276-2281(1999) 2.Guillemare, E., Marion, A., Nisato, D., et al.Inhibitory effects of dronedarone on muscarinic K+ current in guinea pig atrial cellsJ. Cardiovasc. Pharmacol.36(6)802-805(2000) 3.Saengklub, N., Limprasutr, V., Sawangkoon, S., et al.Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillationExp. Anim.66(3)251-258(2017)