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Dorzolamide-d5(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dorzolamide-d5(hydrochloride)图片
规格:98%
分子量:365.9
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22368
CAS:N/A
分子式:C10H11D5N2O4S3.HCl
分子量:365.9
溶解度:DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Dorzolamide-d5is intended for use as an internal standard for the quantification of dorzolamide by GC- or LC-MS. Dorzolamide is an inhibitor of carbonic anhydrase (CA), inhibiting CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV with Kivalues ranging from 3.5 to 52 nM.1,2,3It is selective for these isoforms over CAI, CAIII, and CAIV (Kis = 50, 8, and 8.5 μM, respectively).1Dorzolamide inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% when used at a concentration of 0.02%.3It also reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits when applied topically at a concentration of 0.5%.3Formulations containing dorzolamide have been used in the treatment of glaucoma.4,5


1.Supuran, C.T., and Scozzafava, A.Carbonic anhydrases as targets for medicinal chemistryBioorganic & Medicinal Chemistry15(13)4336-4350(2007) 2.Greer, J., Erickson, J.W., Baldwin, J.J., et al.Application of the three-dimensional structures of protein target molecules in structure-based drug designJournal of Medicinal Chemistry37(8)1035-1054(1994) 3.Hunt, C.A., Mallorga, P.J., Michelson, S.R., et al.3-Substituted thieno[2,3-b][1,4]thiazine-6-sulfonamides. A novel class of topically active carbonic anhydrase inhibitorsJournal of Medicinal Chemistry37(2)240-247(1994) 4.Loftsson, T., Jansook, P., and StefÁnsson, E.Topical drug delivery to the eye: DorzolamideActa. Ophthalmol.90(7)603-608(2012) 5.Cheng, J.W., Cheng, S.W., Gao, L.D., et al.Intraocular pressure-lowering effects of commonly used fixed-combination drugs with Timolol: A systematic review and meta-analysisPLoS One7(9)45079(2012)