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Donepezil-d4(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Donepezil-d4(hydrochloride)图片
规格:98%
分子量:420
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of donepezil
货号:ajcx22362
CAS:1219798-88-5
分子式:C24H25D4NO3.HCl
分子量:420
溶解度:DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 0.5 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Donepezil-d4(hydrochloride) is intended for use as an internal standard for the quantification of donepezil by GC- or LC-MS. Donepezil is a reversible acetylcholinesterase inhibitor (IC50= 23 nM) that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.1As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil has been used to study cognition, memory, and behavior in animal models.2,3


1.MuÑoz-Torrero, D.Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's diseaseCurr. Med. Chem.152433-2455(2008) 2.Ramalingayya, G.V., Nampoothiri, M., Nayak, P.G., et al.Naringin and rutin alleviates episodic memory deficits in two differentially challenged object recognition tasksPharmacogn. Mag.12(Suppl 1)S63-S70(2016) 3.Shumizu, S., Mizuguchi, Y., Sobue, A., et al.Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in miceJ. Pharmacol. Sci.127(4)439-445(2015)