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Clonostachydiol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Clonostachydiol图片
包装:1mg
规格:98%
市场价:2619元
分子量:284.3

产品介绍
Clonostachydiol 是一种来自真菌 Clonostachys cylindrospora(菌株 FH-A 6607)的驱虫大二醇内酯 。
货号:ajcx22108
CAS:2205018-06-8
分子式:C14H20O6
分子量:284.3
溶解度:Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Clonostachydiol is a fungal metabolite originally isolated fromClonostachys cylindrosporathat has anticancer and anthelmintic activities.1,2It is cytotoxic to P388 (IC50= 25 µM), as well as L1210, HT-29, and A549 cancer cells (IC50s = 4.5, 4.2, and 5.7 µg/ml, respectively). Clonostachydiol (2.5 mg/kg, s.c.) reduces fecal worm burden by 80 to 90% in lambs infected with the nematodeH. contortus.1


1.Grabley, S., Hammann, P., Thiericke, R., et al.Secondary metabolites by chemical screening. 21. Clonostachydiol, a novel anthelmintic macrodiolide from the fungus Clonostachys cylindrospora (strain FH-A 6607)J. Antibiot. (Tokyo)46(2)343-345(1993) 2.Lang, G., Mitova, M.I., Ellis, G., et al.Bioactivity profiling using HPLC/microtiter-plate analysis: Application to a New Zealand marine alga-derived fungus, Gliocladium spJ. Nat. Prod.69(4)621-624(2006)