您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Calcium D-Glucarate(hydrate)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Calcium D-Glucarate(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Calcium D-Glucarate(hydrate)图片
规格:98%
分子量:320.3
包装与价格:
包装价格(元)
25g电议
50g电议
100g电议

产品介绍
The calcium salt form of D-glucaric acid
货号:ajcx21966
CAS:5793-89-5
分子式:C6H8O8.Ca [4H2O]
分子量:320.3
溶解度:Methanol: slightly soluble,PBS (pH 7.2): slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Calcium D-glucarate is the calcium salt form of D-glucaric acid.1D-Glucaric acid is an end product of D-glucuronic acid metabolism in mammals that has also been found in fruits and vegetables and has anticancer activity.2It is produced by the oxidation of D-glucuronic acid and is a precursor in the biosynthesis of the β-glucuronidase inhibitor D-glucaro-1,4-lactonein vivo.1Dietary administration of calcium D-glucarate (10% w/w) reduces tumor growth in a rat model of mammary tumorigenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA).3Urinary D-glucaric acid levels have been used as a marker for xenobiotic-induced phase II metabolism in patients with rheumatoid arthritis or individuals exposed to environmental toxicants.4,5


1.Walaszek, Z.Potential use of D-glucaric acid derivatives in cancer preventionCancer Lett.54(1-2)(1990) 2.ZÓ?taszek, R., Hanausek, M., Kiliańska, Z., et al.The biological role of D-glucaric acid and its derivatives: potential use in medicinePostepy. Hig. Med. Dosw. (Online)62451-462(2008) 3.Walaszek, Z., Hanausek-Walaszek, M., Minton, J.P., et al.Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesisCarcinogenesis7(9)1463-1466(1986) 4.Addyman, R., Beyeler, C., Astbury, C., et al.Urinary glucaric acid excretion in rheumatoid arthritis: influence of disease activity and disease modifying drugsAnn. Rheum. Dis.55(7)478-481(1996) 5.IdÉo, G., Bellati, G., Bellohuono, A., et al.Urinary D-glucaric acid excretion in the Seveso area, polluted by tetrachloro-dibenzo-p-dioxin (TCDD): five years of experienceEnviron. Health Perspect.60151-157(1976)