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C18 Ganglioside GM3-d3(d18:1/18:0-d3)(ammonium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
C18 Ganglioside GM3-d3(d18:1/18:0-d3)(ammonium salt)图片
包装:250ug
规格:98%
市场价:6075元
分子量:1201.5

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21916
CAS:N/A
分子式:C59H104D3N2O21.NH4
分子量:1201.5
溶解度:Chloroform:Methanol:Water (2:1:0.1): Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

C18 Ganglioside GM3-d3is intended for use as an internal standard for the quantification of ganglioside GM3by GC- or LC-MS. Ganglioside GM3is a simple monosialoganglioside that demonstrates both antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.1,2When used at a concentration of 20 μM, it suppresses angiogenesis and reduces endothelial cell proliferation and migration by inhibiting VEGFR2 and Akt phosphorylation.1Furthermore, ganglioside GM3has been shown to induce the dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance.3[Matreya, LLC. Catalog No. 2052]


1.Mukherjee, P., Faber, A.C., Shelton, L.M., et al.Thematic review series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1aJ. Lipid Res.49(5)929-938(2008) 2.Seyfried, T.N., and Mukherjee, P.Ganglioside GM3 is antiangiogenic in malignant brain cancerJ. Oncol.961243(2010) 3.Kabayama, K., Sato, T., Saito, K., et al.Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistanceProc. Natl. Acad. Sci. USA104(34)13678-13683(2007)