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Bicalutamide-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bicalutamide-d4图片
规格:98%
分子量:434.4
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
比卡鲁胺-d4 是氘标记的比卡鲁胺。比卡鲁胺是一种口服活性的非甾体雄激素受体 (AR) 拮抗剂。比卡鲁胺可用于前列腺癌的研究。
货号:ajcx21802
CAS:1185035-71-5
分子式:C18H10D4F4N2O4S
分子量:434.4
溶解度:DMSO: Soluble,Methanol: Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Bicalutamide-d4is intended for use as an internal standard for the quantification of bicalutamide by GC- or LC-MS. Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (Ki= 12.5 μM; IC50= 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones.1,2Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.3,4


1.Freeman, S.N., Mainwaring, W.I.P., and Furr, B.J.A.A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176,334)Br. J. Cancer60(5)664-668(1989) 2.Masiello, D., Cheng, S., Bubley, G.J., et al.Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptorThe Journal of Biological Chemisty277(29)26321-26326(2002) 3.Gao, W., Kim, J., and Dalton, J.T.Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligandsPharmaceutical Research23(8)1641-1658(2006) 4.Yin, D., Perera, M.A., Dalton, J.T., et al.Key structural features of nonsteroidal ligands for binding and activation of the androgen receptorMolecular Pharmacology63(1)211-223(2003)