| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 3185元 |
| 分子量: | 467.6 |
Background:
AS-2077715 is a fungal metabolite and an inhibitor of fungal mitochondrial complex III (cytochrome bc1; IC50= 80 ng/ml forT. mentagrophytescomplex III).1It is selective for fungal over mammalian complex III (IC50s = 480 and 860 ng/ml for murine EL-4 cell and human Jurkat cell complex III, respectively). AS-2077715 inhibits ATP production in (IC50= 0.33 µg/ml) and is fungicidal againstT. mentagrophyteswhen used at concentrations of 1 and 10 µg/ml.In vivo, AS-2077715 (10 and 20 mg/kg) reduces the number of foot pad skin colony forming units (CFUs) in a guinea pig model ofT. mentagrophytesinfection.2
1.Ohsumi, K., Watanabe, M., and Fujie, A.AS2077715 Is a selective inhibitor of fungal mitochondrial cytochrome Bc? complexJ. Antibiot. (Tokyo)67(10)713-716(2014) 2.Ohsumi, K., Murai, H., Nakamura, I., et al.Therapeutic efficacy of AS2077715 against experimental tinea pedis in guinea pigs in comparison with terbinafineJ. Antibiot. (Tokyo)67(10)717-719(2014)
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