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Nifurtimox-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nifurtimox-d4图片
包装:1mg
规格:98%
市场价:7394元
分子量:291.3

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx20096
CAS:N/A
分子式:C10H9D4N3O5S
分子量:291.3
溶解度:Acetonitrile:Methanol (1:1): soluble,DMSO: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Nifurtimox-d4 is intended for use as an internal standard for the quantification of nifurtimox by GC- or LC-MS. Nifurtimox is an antiprotozoal agent.1 It is active against TaluahuÉn, LQ, and Brener strains of T. cruzi epimastigotes (IC50s = 9.91, 12.28, and 10.44 μM, respectively). Nifurtimox interferes with cellular oxygen metabolism and induces parasitic cell death through the production of highly toxic oxygen reactive metabolites, including superoxide anions, hydroxyl radicals, and hydrogen peroxide. It also inhibits clonogenic growth of HCT116, H838, C33A, LN18, KNS42, MDA-MB-231, and FaDu human cancer cells under hypoxic conditions.2 Formulations containing nifurtimox have been used in the treatment of Chaga's disease.3


|1. Maya, J.D., Bollo, S., Nu•ez-Vergara, L.J., et al. Trypanosoma cruzi: Effect and mode of action of nitroimidazole and nitrofuran derivatives. Biochem. Pharmacol. 65(6), 999-1006 (2003).|2. Li, Q., Lin, Q., Kim, H., et al. The anti-protozoan drug nifurtimox preferentially inhibits clonogenic tumor cells under hypoxic conditions. Am. J. Cancer Res. 7(5), 1084-1095 (2017).|3. Pinazo, M.-J., Guerrero, L., Posada, E., et al. Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic chagas disease. Antimicrob. Agents Chemother. 57(1), 390-395 (2013).