| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 4815元 |
| 分子量: | 361.3 |
Background:
Balsalazide-d4 is intended for use as an internal standard for the quantification of balsalazide by GC- or LC-MS. Balsalazide is a prodrug form of 5-aminosalicylic acid .1 It is cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA. Balsalazide (600 mg/kg per day) decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of colitis induced by 2,4-dinitrochlorobenzene (DNCB).2 Formulations containing balsalazide have been used in the treatment of ulcerative colitis.
|1. Tursi, A. Balsalazide in treating colonic diseases. Expert Opin. Drug Metab. Toxicol. 5(12), 1555-1563 (2009).|2. Lu, Y.-X., and Chen, X.-M. Effects of balsalazide on experimental colitis induced by 2,4-dinitrochlorobenzene in rats. Zhongguo Xinyao Yu Linchuang Zazhi 26(12), 901-904 (2007).
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