| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 3333元 |
| 分子量: | 501.7 |
Background:
GKK1032B is a fungal metabolite originally isolated from Penicillium sp. GKK1032 that has antiproliferative and antibacterial activities.1,2 GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells (IC50s = 17.7 and 14.71 μM, respectively) and Vero cells (IC50 = 29.55 μM). It also inhibits the growth of B. subtilis (MIC = 20.8 μg/ml) and M. tuberculosis (MIC = 48.35 μM).
|1. Li, X.-W., Ear, A., and Nay, B. Hirsutellones and beyond: Figuring out the biological and synthetic logics toward chemical complexity in fungal PKS-NRPS compounds. Nat. Prod. Rep. 30(6), 765-782 (2013).|2. Rukachaisirikul, V., Satpradit, S., Klaiklay, S., et al. Polyketide anthraquinone, diphenyl ether, and xanthone derivatives from the soil fungus Penicillium sp. PSU-RSPG99. Tetrahedron 70(34), 5148-5152 (2014).
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