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Aztreonam-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aztreonam-d6图片
包装:500ug
规格:98%
市场价:4430元
分子量:441.5

产品介绍
An internal standard for the quantification of aztreonam
货号:ajcx20048
CAS:1127452-94-1
分子式:C13H11D6N5O8S2
分子量:441.5
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Aztreonam-d6 is intended for use as an internal standard for the quantification of aztreonam by GC- or LC-MS. Aztreonam is a synthetic β-lactam antibiotic of the monobactam class.1 It is active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = <0.1, 1.2, 5.2, 3.1, <0.1, and 19.3 μg/ml, respectively) but is inactive against S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 μg/ml for all). It interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 μg/ml for all). It increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg). Formulations containing aztreonam have been used in the treatment of P. aeruginosa infections in individuals with cystic fibrosis.


|1. Sykes, R.B., Bonner, D.P., Bush, K., et al. Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria. Antimicrob. Agents Chemother. 21(1), 85-92 (1982).