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Deferiprone-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Deferiprone-d3图片
包装:1mg
规格:98%
市场价:1496元
分子量:142.2

产品介绍
An internal standard for the quantification of deferiprone
货号:ajcx19988
CAS:1346601-82-8
分子式:C7H6D3NO2
分子量:142.2
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Deferiprone-d3 is intended for use as an internal standard for the quantification of deferiprone by GC- or LC-MS. Deferiprone is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio and has antioxidant and neuroprotective activities.1 It reduces levels of intracellular iron and inhibits lipid peroxidation in primary rat hepatocytes when used at concentrations of 200 and 50 μM, respectively.2 Deferiprone reduces cholesterol diet-induced increases in the levels of amyloid-β (1-42) (Aβ42), Aβ40, and the phosphorylation of tau and glycogen synthase kinase 3β (GSK3β) in the rabbit hippocampus when administered at a dose of 50 mg/kg.3 Formulations containing deferiprone have been used in the treatment of thalassemia.


|1. BarnabÉ, N., Zastre, J.A., Venkataram, S., et al. Deferiprone protects against doxorubicin-induced myocyte cytotoxicity. Free Radic. Biol. Med. 33(2), 266-275 (2002).|2. Morel, I., Cillard, J., Lescoat, G., et al. Antioxidant and free radical scavenging activities of the iron chelators pyoverdin and hydroxypyrid-4-ones in iron-loaded hepatocyte cultures: Comparison of their mechanism of protection with that of desferrioxamine. Free Radic. Biol. Med. 13(5), 499-508 (1992).|3. Prasanthi, J.R., Schrag, M., Dasari, B., et al. Deferiprone reduces amyloid-β and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet. J. Alzheimers Dis. 30(1), 167-182 (2012).