Etoposide-d3 is intended for use as an internal standard for the quantification of etoposide by GC- or LC-MS.
货号:ajcx17522
CAS:N/A
分子式:C29H29D3O13
分子量：591.6
溶解度:Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Etoposide-d3 is intended for use as an internal standard for the quantification of etoposide by GC- or LC-MS. Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 μM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM). It reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model when administered at a dose of 25 mg/kg, an effect that is enhanced by concomitant administration of the immunosuppressant cyclosporin A . Etoposide also inhibits nuclear receptor coactivator 3 (IC50 = 2.48 µM). Formulations containing etoposide have been used in combination therapy in the treatment of cancer.