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Diphyllin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Diphyllin图片
规格:98%
分子量:380.35
包装与价格:
包装价格(元)
10mg电议
25mg电议

产品介绍
Diphyllin 是一种从 Justicia procumbens 中分离出的芳基萘木脂素,是一种有效的 HIV-1 抑制剂,IC50 为 0.38 μM。Diphyllin 还具有抗水泡性口炎病毒 (VSV) 和流感病毒的活性。Diphyllin 是 V-ATPase 的抑制剂,IC50 值为 17 nM,可抑制人破骨细胞中的溶酶体酸化。Diphyllin 以 IC50 值为 50 μM 来抑制 NO 产生,并具有抗癌和抗炎活性。
货号:ajcx17200
CAS:22055-22-7
分子式:C21H16O7
分子量:380.35
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus[1]. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts[2]. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities[3].


[1]. Xin-Ya Xu, et al. Anti-HIV Lignans From Justicia Procumbens. Chin J Nat Med. 2019 Dec;17(12):945-952. [2]. Mette G SØrensen, et al. Diphyllin, a Novel and Naturally Potent V-ATPase Inhibitor, Abrogates Acidification of the Osteoclastic Resorption Lacunae and Bone Resorption. J Bone Miner Res. 2007 Oct;22(10):1640-8. [3]. Yerra Koteswara Rao, et al. Anti-inflammatory Activities of Constituents Isolated From Phyllanthus Polyphyllus. J Ethnopharmacol. 2006 Jan 16;103(2):181-6.