Thalidomide-NH-C6-NH-Boc 是一种合成的 E3 连接酶配体-连接蛋白偶联物 (E3 ligase ligand-linker conjugate)，结合了基于 cereblon 配体的 Thalidomide 和连接蛋白，用于合成 MI-389 (化合物 22)。MI-389 是一种基于多靶点受体酪氨酸激酶抑制剂舒尼替尼 的 PROTAC 降解剂。
货号:ajcx17188
CAS:2093536-13-9
分子式:C24H32N4O6
分子量：472.53
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used for MI-389 (compound 22) synthesis. MI-389 is a potent phthalimide PROTAC degrader based on the multi-targeted receptor tyrosine kinase inhibitor sunitinib [1].

[1]. Mette Ishoey, et al. Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders.ACS Chem Biol. 2018 Mar 16;13(3):553-560.