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PC945
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PC945图片
规格:98%
分子量:682.73
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
PC945 是一种有效的抗真菌 (antifungal) 三唑类药物,对多种敏感和耐药的烟曲霉菌株都具有抗药性。PC945 是烟曲霉甾醇 14α-去甲基酶 (CYP51A/CYP51B) 活性的有效、紧密结合的抑制剂,IC50s 分别为 0.23 μM 和 0.22 μM。
货号:ajcx17006
CAS:1931946-73-4
分子式:C38H37F3N6O3
分子量:682.73
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively[1][2].


[1]. Colley T, et al. In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16. [2]. Colley T, et al. Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection. Sci Rep. 2019 Jul 1;9(1):9482.