WIN site inhibitor 1 TFA 是一种染色质相关 WD 重复结构域 5 蛋白 (WDR5) 的 WIN 位点抑制剂，Kd 值为 0.1 nM。WIN site inhibitor 1 TFA 能够从染色质中取代 WDR5，并降低相关基因的表达，引起翻译抑制和核仁应激。具有抗癌作用。
货号:ajcx16672
CAS:N/A
分子式:C27H23Cl2F4N5O3
分子量：612.4
溶解度:DMSO: ≥ 250 mg/mL (408.23 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

WIN site inhibitor 1 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WIN site inhibitor 1 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity[1].

[1]. Aho ER, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.