CAS NO: | 95604-83-4 |
规格: | ≥98% |
包装 | 价格(元) |
5mg | 电议 |
50mg | 电议 |
500mg | 电议 |
MM 159 (Probimane) is an anticancer agent and specifically targets cancer metastasis and is a cardioprotectant of anthrocyclines. MM 159 is active against more categories of tumors both in vivo and in vitro, which in some circumstances may make it superior to the currently-used anticancer bisdioxopiperazines, including razoxane and MST-16. References: Lu DY, Chen RT, Lu TR, Wu HY, Qu RX, Che JY, Xu B. Absorption, distribution and excretion of 14C-probimane in mice bearing lewis lung carcinoma. Sci Pharm. 2010;78(3):445-50. doi: 10.3797/scipharm.1005-05. Epub 2010 Jun 15. PubMed PMID: 21179357; PubMed Central PMCID: PMC3002815. 2: Lu DY, Lu TR. Anticancer activities and mechanisms of bisdioxopiperazine compounds probimane and MST-16. Anticancer Agents Med Chem. 2010 Jan;10(1):78-91. Review. PubMed PMID: 19845502. 3: Dan N, Li XJ, Zhao BL, Zhang TM, Xin WJ. [Scavenging effects of probimane on active oxygen free radicals by electron spin resonance]. Zhongguo Yao Li Xue Bao. 1989 Sep;10(5):443-7. Chinese. PubMed PMID: 2559581. 4: Lu DY, Huang M, Xu CH, Zhu H, Xu B, Ding J. Medicinal chemistry of probimane and MST-16: comparison of anticancer effects between bisdioxopiperazines. Med Chem. 2006 Jul;2(4):369-75. PubMed PMID: 16848748. 5: Lu DY, Huang M, Xu CH, Yang WY, Hu CX, Lin LP, Tong LJ, Li MH, Lu W, Zhang XW, Ding J. Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation by probimane and MST-16 in human tumor cell lines. BMC Pharmacol. 2005 Jun 20;5:11. PubMed PMID: 15963241; PubMed Central PMCID: PMC1180833. 6: Zhang Y, Ye QX, Liu J, Zhang ZY, Zhang TM. Synergistic effect of probimane on anticancer cytotoxicity of doxorubicin in vitro. Zhongguo Yao Li Xue Bao. 1994 Jan;15(1):56-9. PubMed PMID: 8010087. 7: Lu DY, Xu B, Zhang X, Chen RT. [Distribution of 14C labeled at dioxopiperazine or methyl morpholine group of probimane by whole body autoradiography]. Zhongguo Yao Li Xue Bao. 1993 Mar;14(2):171-3. Chinese. PubMed PMID: 8352014. 8: Zhang Y, Zhang TM, Zhao BL, Han JK, Chen WC, Xin WJ. [Scavenging of probimane on semiquinone free radical formation by doxorubicin in rat heart]. Zhongguo Yao Li Xue Bao. 1991 Jan;12(1):20-3. Chinese. PubMed PMID: 1950578. 9: Wang MY, Liu TX, Li GD, Zhang TM. [Effects of bimolane and probimane on the incorporation of (3H)TdR, (3H)UR and (3H)Leu into Ehrlich ascites carcinoma cells iv vitro]. Zhongguo Yao Li Xue Bao. 1988 Jul;9(4):367-9. Chinese. PubMed PMID: 3195348. 10: Zhang TM, Wang MY, Wang QD, Ren YF. [Antineoplastic action and toxicity of probimane and its effect on immunologic functions in mice]. Zhongguo Yao Li Xue Bao. 1987 Jul;8(4):369-74. Chinese. PubMed PMID: 3502223.
纯度:≥98%
CAS:95604-83-4