TUG-1375是一种游离脂肪酸受体2(FFA2/GPR43)激动剂，pKi值为6.69。TUG-1375对FFA3，FFA4，PPARα，PPARγ，PPARδ，LXRα或LXRβ无作用。
货号:ajcx13644
CAS:2247372-59-2
分子式:C22H19ClN2O4S
分子量：442.92
溶解度:DMSO : 125 mg/mL (282.22 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ[1]. pKi: 6.69 (FFA2)[1]

TUG-1375 exhibits pEC50 of 7.11 in the cAMP FFA2 assay, also active on murine FFA2 orthologue (pEC50, 6.44 ± 0.13 in the cAMP assay)[1].

[1]. Hansen AH, et al. Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61(21):9534-9550.