NeurokininA(4-10)TFA是速激肽NK2受体激动剂。
货号:ajcx13606
CAS:N/A
分子式:C36H55F3N8O12S
分子量：880.93
溶解度:H2O :< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist[1]. NK2 receptor[1]

Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding[1].

[1]. Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.