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CARM1-IN-1 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CARM1-IN-1 hydrochloride图片
规格:98%
分子量:591.72
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
CARM1-IN-1盐酸盐是CARM1高效选择性抑制剂,IC50值为8.6uM,对PRMT1和SET7抑制活性很抵。
货号:ajcx13548
CAS:N/A
分子式:C26H22Br2ClNO3
分子量:591.72
溶解度:DMSO : ≥ 38 mg/mL (64.22 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CARM1-IN-1 hydrochloride is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 >600 uM). IC50 value: 8.6 uM [1]Target: CRAM1 inhibitorin vitro: CARM1-IN-1 displays high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, CARM1-IN-1 shows a significant dose-dependent reduction of the PSA promoter activity.


[1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.