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Carnostatine(SAN9812)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carnostatine(SAN9812)图片
规格:98%
分子量:256.26
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
Carnostatine(SAN9812)是一种特异性和高选择性的肌肽酶(CN1)抑制剂,Ki为11nM。
货号:ajcx13394
CAS:N/A
分子式:C10H16N4O4
分子量:256.26
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Carnostatine (SAN9812) is a specific and highly selective carnosinase (CN1) inhibitor with a Ki of 11 nM.

Carnostatine (SAN9812) is a potent CN1 activity inhibitor with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 µM, i.e., close to the Km of 190 µM. Carnostatine is a competitive inhibitor, showing a right-shift in its IC50 value with increasing carnosine concentration. The Ki value of Carnostatine is determined as 11 nM[1].

CN1 activity is measured after a single subcutaneous bolus of 30 mg/kg Carnostatine (SAN9812). Animals are stratified according to their baseline serum carnosinase activity into a high-activity- (>250 µmol/mL/h) and a low-activity ( 8 h. At the last sampling time point 16 h after Carnostatine administration, serum carnosinase activity is still reduced by 40% in the low-activity group and by 75% in the high-activity group[1].

[1]. Qiu J, et al. Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity. Amino Acids. 2018 Jun 20.