PAK-IN-1是PAK的抑制剂，对groupII具有选择性。PAK-IN-1抑制PAK4，PAK5和PAK6的IC50值分别为7.5，36和126nM。
货号:ajcx13066
CAS:1394121-05-1
分子式:C22H26N6O2
分子量：406.48
溶解度:DMSO: 270 mg/mL (664.24 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PAK-IN-1 is a PAK inhibitor that displays group II selectivity. PAK-IN-1 inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively.

PAK-IN-1 is compound 4 from the reference[1].

[1]. Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett. 2015 May 22;6(7):776-81.